People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …

The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Lung epithelial cells are increasingly recognized to be active effectors of microbial defense,
contributing to both innate and adaptive immune function in the lower respiratory tract. As …

Respiratory viruses are frequent causes of repeated common colds, bronchitis and
pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those …

Besides providing an essential protective barrier, airway epithelial cells directly sense
pathogens and respond defensively. This is a frontline component of the innate immune …

Bacterial pneumonias cause disproportionate morbidity and mortality in patients with cancer,
despite the current aggressive use of prophylactic antibiotics and environmental hygiene …

Pneumonia is initiated by microbes in the lung, but physiological processes integrating
responses across diverse cell types and organ systems dictate the outcome of respiratory …

Neutropenic cancer patients have numerous potential causes for pulmonary infiltrates and
clinical deterioration, with lower respiratory tract infections among the most deadly. Early …

Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although
triggered by a pathogen, pneumonia often results from dysregulations of host defense that …