Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

It has been known for over 100 years that acidosis decreases the contractility of cardiac
muscle. However, the mechanisms underlying this decrease are complicated because …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The major physiological stimulus for the secretion of insulin from the pancreatic β-cell is an
increase in the plasma glucose concentration. It is well established that glucose-stimulated …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

The cardiac ryanodine receptor (RyR2) governs the release of Ca2+ from the sarcoplasmic
reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to …

Carvedilol is one of the most effective beta blockers for preventing ventricular
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …

Ventricular tachycardia (VT) is the leading cause of sudden death, and the cardiac
ryanodine receptor (RyR2) is emerging as an important focus in its pathogenesis. RyR2 …

To investigate the extent to which the properties of the cardiac myofibrils contribute to the
length-force relation of cardiac muscle, we determined the sarcomere length-force relations …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …