Posttranslational regulation of HMG CoA reductase, the rate-limiting enzyme in synthesis of cholesterol
MM Schumacher… - Annual review of …, 2021 - annualreviews.org
The polytopic, endoplasmic reticulum (ER) membrane protein 3-hydroxy-3-methylglutaryl
coenzyme A (HMG CoA) reductase produces mevalonate, the key intermediate in the …
coenzyme A (HMG CoA) reductase produces mevalonate, the key intermediate in the …
Post-translational regulation of HMG CoA reductase
Y Jo, RA DeBose-Boyd - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an endoplasmic reticulum
(ER)-localized integral membrane protein that catalyzes the rate-limiting step in the …
(ER)-localized integral membrane protein that catalyzes the rate-limiting step in the …
[HTML][HTML] Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
SY Jiang, H Li, JJ Tang, J Wang, J Luo, B Liu… - Nature …, 2018 - nature.com
Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …
[HTML][HTML] Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …
[PDF][PDF] Ubiquitin-dependent degradation of mitochondrial proteins regulates energy metabolism
J Lavie, H De Belvalet, S Sonon, AM Ion, E Dumon… - Cell reports, 2018 - cell.com
The ubiquitin proteasome system (UPS) regulates many cellular functions by degrading key
proteins. Notably, the role of UPS in regulating mitochondrial metabolic functions is unclear …
proteins. Notably, the role of UPS in regulating mitochondrial metabolic functions is unclear …
[HTML][HTML] Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the …
Cholesterol synthesis is a highly oxygen-consuming process. As such, oxygen deprivation
(hypoxia) limits cholesterol synthesis through incompletely understood mechanisms …
(hypoxia) limits cholesterol synthesis through incompletely understood mechanisms …
[HTML][HTML] Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
M Juneja, D Kobelt, W Walther, C Voss, J Smith… - PLoS …, 2017 - journals.plos.org
MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker
for cancer progression and metastasis in a large variety of solid tumor types, particularly …
for cancer progression and metastasis in a large variety of solid tumor types, particularly …
Degradation versus inhibition: development of proteolysis-targeting chimeras for overcoming statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl …
MX Li, Y Yang, Q Zhao, Y Wu, L Song… - Journal of Medicinal …, 2020 - ACS Publications
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an eight-pass
transmembrane protein in the endoplasmic reticulum (ER) and a classical drug target to treat …
transmembrane protein in the endoplasmic reticulum (ER) and a classical drug target to treat …
[HTML][HTML] Post-translational control of the long and winding road to cholesterol
The synthesis of cholesterol requires more than 20 enzymes, many of which are intricately
regulated. Post-translational control of these enzymes provides a rapid means for modifying …
regulated. Post-translational control of these enzymes provides a rapid means for modifying …
[HTML][HTML] Revised model of the tissue factor pathway of thrombin generation: role of the feedback activation of FXI
HHS Lakshmanan, A Estonilo, SE Reitsma… - Journal of Thrombosis …, 2022 - Elsevier
Background Biochemical reaction networks are self‐regulated in part due to feedback
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …