The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

Neuronal diversity is essential for mammalian brain function but poses a challenge to
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Methods for single-cell genome and transcriptome sequencing have contributed to our
understanding of cellular heterogeneity, whereas methods for single-cell epigenomics are …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …