Involvement of oxidative stress in the development of subcellular defects and heart disease
NS Dhalla, V Elimban, M Bartekova, A Adameova - Biomedicines, 2022 - mdpi.com
It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …
activation of proteases, fragmentation of DNA and alteration in gene expression for …
The multifaceted ATPase inhibitory factor 1 (IF1) in energy metabolism reprogramming and mitochondrial dysfunction: a new player in age-associated disorders?
E Gore, T Duparc, A Genoux, B Perret… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
The inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex
J Carroll, IN Watt, CJ Wright, S Ding, IM Fearnley… - Journal of Biological …, 2024 - ASBMB
The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein
called IF 1, but bovine IF 1 has no effect on the synthetic activity of the bovine enzyme in …
called IF 1, but bovine IF 1 has no effect on the synthetic activity of the bovine enzyme in …
[HTML][HTML] F-ATP synthase inhibitory factor 1 and mitochondria-organelle interactions: New insight and implications
L Guo - Pharmacological research, 2024 - Elsevier
Mitochondria are metabolic hub, and act as primary sites for reactive oxygen species (ROS)
and metabolites generation. Mitochondrial Ca 2+ uptake contributes to Ca 2+ storage …
and metabolites generation. Mitochondrial Ca 2+ uptake contributes to Ca 2+ storage …
Unilateral acute renal ischemia-reperfusion injury induces cardiac dysfunction through intracellular calcium mishandling
CVC Junho, L González-Lafuente… - International journal of …, 2022 - mdpi.com
Background: Acute renal failure (ARF) following renal ischemia-reperfusion (I/R) injury is
considered a relevant risk factor for cardiac damage, but the underlying mechanisms …
considered a relevant risk factor for cardiac damage, but the underlying mechanisms …
Antisense therapy attenuates phospholamban p.(Arg14del) cardiomyopathy in mice and reverses protein aggregation
TR Eijgenraam, NM Stege… - International Journal of …, 2022 - mdpi.com
Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the
phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and …
phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and …
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling
KT Nijholt, PI Sánchez-Aguilera, HG Booij… - Scientific Reports, 2023 - nature.com
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes
physiological hypertrophy in vitro. The purpose of this study is to determine if AKIP1 …
physiological hypertrophy in vitro. The purpose of this study is to determine if AKIP1 …
[HTML][HTML] IF1 Promotes Cellular Proliferation and Inhibits Oxidative Phosphorylation in Mouse Embryonic Fibroblasts under Normoxia and Hypoxia
ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP
synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is …
synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is …
Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway
D Qian, J Tian, S Wang, X Shan, P Zhao… - … medicine and therapies, 2022 - Springer
Background Trans-cinnamaldehyde (TCA) is one of the main pharmaceutical ingredients of
Cinnamomum cassia Presl, which has been shown to have therapeutic effects on a variety …
Cinnamomum cassia Presl, which has been shown to have therapeutic effects on a variety …
Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure
M Szibor, M Mühlon, T Doenst… - Frontiers in Molecular …, 2023 - frontiersin.org
Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy
metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a …
metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a …