The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

The NF-κB family of dimeric transcription factors regulates transcription by selectively
binding to DNA response elements present within promoters or enhancers of target genes …

For many decades, glucocorticoids have been widely used as the gold standard treatment
for inflammatory conditions. Unfortunately, their clinical use is limited by severe adverse …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …

The type II nuclear receptors (NRs) function as heterodimeric transcription factors with the
retinoid X receptor (RXR) to regulate diverse biological processes in response to …

Single-molecule tracking (SMT) allows the study of transcription factor (TF) dynamics in the
nucleus, giving important information regarding the diffusion and binding behavior of these …

Uncovering the mechanisms that affect the binding specificity of transcription factors (TFs) is
critical for understanding the principles of gene regulation. Although sequence-based …

Spatial and temporal expression of genes is essential for maintaining phenotype integrity.
Transcription factors (TFs) modulate expression patterns by binding to specific DNA …

The transcription factor MYC is a proto‐oncogene with a well‐documented essential role in
the pathogenesis and maintenance of several types of cancer. MYC binds to specific E‐box …