Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in the
haemopoietic stem cell (HSC) compartment. This disease is characterised by a reciprocal t …

Preclinical studies of BCR-ABL mutation sensitivity to nilotinib or dasatinib suggested that
the majority would be sensitive. Correspondingly, the initial clinical trials demonstrated …

Chronic myelogenous leukemia (CML), characterized by the BCR-ABL gene rearrangement,
has been extensively studied. Significant progress has been made in the area of BCR-ABL …

The prevalence of obesity, an established epidemiological risk factor for many cancers, has
risen steadily for the past several decades in the US and many other countries. Particularly …

Humans are exposed to a wide variety of carcinogenic insults, including endogenous and
man-made chemicals, radiation, physical agents, and viruses. The ultimate goal of …

The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a
vital role in maintaining genomic stability and regulating cellular responses to stress …

Aberrant DNA methylation of tumor suppressor genes has been reported in all major types
of leukemia with potential involvement in the inactivation of regulatory cell cycle and …

The expression of the suppressor of cytokine signalling‐1 (SOCS1) protein is induced in
response to stimulation by several cytokines. The induced SOCS1 inhibits the signalling …

The transformation of chronic myeloid leukemia (CML) from a chronic phase to an acute
phase is frequently accompanied by additional chromosome changes. Extensive …