Single B cell technologies for monoclonal antibody discovery
A Pedrioli, A Oxenius - Trends in immunology, 2021 - cell.com
Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …
Antigen receptor repertoire profiling from RNA-seq data
To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result
in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …
in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …
Predicting evolution
M Lässig, V Mustonen, AM Walczak - Nature ecology & evolution, 2017 - nature.com
The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …
predicting future evolutionary processes. Recent developments include prediction of …
[HTML][HTML] Methods and applications of CRISPR-mediated base editing in eukaryotic genomes
The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
A large-scale systematic survey reveals recurring molecular features of public antibody responses to SARS-CoV-2
Global research to combat the COVID-19 pandemic has led to the isolation and
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
characterization of thousands of human antibodies to the SARS-CoV-2 spike protein …
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding
Antibody-antigen binding relies on the specific interaction of amino acids at the paratope-
epitope interface. The predictability of antibody-antigen binding is a prerequisite for de novo …
epitope interface. The predictability of antibody-antigen binding is a prerequisite for de novo …
OLGA: fast computation of generation probabilities of B-and T-cell receptor amino acid sequences and motifs
Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …
development of methods to predict the probability of generation by V (D) J recombination of …