The protein inhibitor of activated STAT (PIAS) family of proteins has been proposed to
regulate the activity of many transcription factors, including signal transducer and activator of …

Glucocorticoids are a vital class of endogenous steroid hormones that regulate essential
biological processes including growth, development, metabolism, behavior and apoptosis …

The heat shock response, which is accompanied by a rapid and robust upregulation of heat
shock proteins (Hsps), is a highly conserved protection mechanism against protein …

Abstract Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear
protein aggregates. To gain insight in PML-NB function, reductionist and high throughput …

SUMO (small ubiquitin-related modifier) family proteins are not only structurally but also
mechanistically related to ubiquitin in that they are posttranslationally attached to other …

The molecular mechanisms by which Notch receptors induce diverse biological responses
are not fully understood. We recently cloned a mammalian homologue of the Mastermind …

During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

To identify deneddylases, proteases with specificity for hydrolysis of Nedd8 derivatives, a
facile method was developed for the synthesis of Nedd8 amidomethylcoumarin (a substrate) …

In the first part of our review (see Pharmacol Rev 2002; 54: 129-158), we discussed the
basic principles of gene transcription and the complex interactions within the network of …

The E1 proteins are the essential origin recognition proteins for papillomavirus (PV)
replication. E1 proteins bind to specific DNA elements in the viral origin of replication and …