Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland.
Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti …

Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels
that contribute to the modulation of a number of physiological functions in a variety of cell …

Colon cancer cells, like other types of cancer cells, undergo the remodeling of the
intracellular Ca 2+ homeostasis that contributes to cancer cell hallmarks including enhanced …

The intracellular calcium signaling processes are tightly regulated to ensure the generation
of calcium signals with the specific spatiotemporal characteristics required for regulating …

In recent decades cancer emerged as one of the leading causes of death in the developed
countries, with some types of cancer contributing to the top 10 causes of death on the list of …

Background Developing new strategies to reduce the output power of microwave (MW)
ablation while keeping anti-tumor effect are highly desirable for the simultaneous …

Store-operated Ca2+ entry (SOCE) is the most important Ca2+ entry pathway in non-
excitable cells. Colorectal cancer (CRC) shows decreased Ca2+ store content and …

Calcium (Ca2+) is a key second messenger in eukaryotes, with store-operated Ca2+ entry
(SOCE) being the main source of Ca2+ influx into non-excitable cells. ORAI1 is a highly …

About 15% of patients with parkinsonism have a hereditary form of Parkinson's disease
(PD). Studies on the early stages of PD pathogenesis are challenging due to the lack of …