Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

The mechanism of Bax/Bak activation remains a central question in mitochondria-dependent
apoptotic signaling. While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only …

The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a
large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that …

The BCL-2 family protein BAX is a major regulator of physiological and pathological cell
death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it …

Although the concept of programmed cell death (PCD) in bacteria has been met with
scepticism, a growing body of evidence suggests that it can no longer be ignored. Several …

It has been widely accepted that mitochondria-dependent apoptosis initiates when select
BH3-only proteins (BID, BIM, etc.) directly engage and allosterically activate effector proteins …

The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-
apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by …