Animal models for osteoporosis
T Komori - European journal of pharmacology, 2015 - Elsevier
The major types of osteoporosis in humans are postmenopausal osteoporosis, disuse
osteoporosis, and glucocorticoid-induced osteoporosis. Animal models for postmenopausal …
osteoporosis, and glucocorticoid-induced osteoporosis. Animal models for postmenopausal …
Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: relevance to depression
EY Sterner, LE Kalynchuk - Progress in Neuro-Psychopharmacology and …, 2010 - Elsevier
Stress is a critical environmental trigger for the development of clinical depression, yet little
is known about the specific neurobiological mechanisms by which stress influences the …
is known about the specific neurobiological mechanisms by which stress influences the …
Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models
BM Andrus, K Blizinsky, PT Vedell, K Dennis… - Molecular …, 2012 - nature.com
The etiology of depression is still poorly understood, but two major causative hypotheses
have been put forth: the monoamine deficiency and the stress hypotheses of depression. We …
have been put forth: the monoamine deficiency and the stress hypotheses of depression. We …
Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex
Emerging evidence has shown the low levels of glutamate (Glu) and glutamine (Gln) and the
hypoactivity in the cortex of patients with depression. The hypoactivity is closely related with …
hypoactivity in the cortex of patients with depression. The hypoactivity is closely related with …
Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders
V Walia, SK Chaudhary, NK Sethiya - Neurochemistry international, 2021 - Elsevier
Xanthones are important chemical class of bioactive products that confers therapeutic
benefits. Of several xanthones, mangiferin is known to be distributed widely across several …
benefits. Of several xanthones, mangiferin is known to be distributed widely across several …
[HTML][HTML] A chronic immobilization stress protocol for inducing depression-like behavior in mice
Depression is not yet fully understood, but various causative factors have been reported.
Recently, the prevalence of depression has increased. However, therapeutic treatments for …
Recently, the prevalence of depression has increased. However, therapeutic treatments for …
Developing better and more valid animal models of brain disorders
AM Stewart, AV Kalueff - Behavioural brain research, 2015 - Elsevier
Valid sensitive animal models are crucial for understanding the pathobiology of complex
human disorders, such as anxiety, autism, depression and schizophrenia, which all have the …
human disorders, such as anxiety, autism, depression and schizophrenia, which all have the …
Gene expression studies in major depression
The dramatic technical advances in methods to measure gene expression on a genome-
wide level thus far have not been paralleled by breakthrough discoveries in psychiatric …
wide level thus far have not been paralleled by breakthrough discoveries in psychiatric …
Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice
Background: The brain levels of glutamate (Glu) and glutamine (Gln) are partially regulated
through the Glu–Gln cycle. Astrocytes play a role in regulating the Glu–Gln cycle, and loss of …
through the Glu–Gln cycle. Astrocytes play a role in regulating the Glu–Gln cycle, and loss of …
Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice
The ventral striatum is a reward center implicated in the pathophysiology of depression. It
contains islands of Calleja, clusters of dopamine D3 receptor-expressing granule cells …
contains islands of Calleja, clusters of dopamine D3 receptor-expressing granule cells …