Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Y Zhang, Q Liu, Q Liao - Journal of Experimental & Clinical Cancer …, 2020 - Springer
Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that
are highly linked to various cellular functions and pathological process. Emerging evidence …

miRNAs and lncRNAs as novel therapeutic targets to improve cancer immunotherapy

MT Di Martino, C Riillo, F Scionti, K Grillone, N Polerà… - Cancers, 2021 - mdpi.com
Simple Summary Cancer onset and progression are promoted by high deregulation of the
immune system. Recently, major advances in molecular and clinical cancer immunology …

HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis

C Zhong, B Tao, X Li, W Xiang, L Peng, T Peng… - Cell Death & …, 2022 - nature.com
Long non-coding RNAs (lncRNAs) have been manifested to manipulate diverse biological
processes, including tumor-induced immune tolerance. Thus, we aimed in this study to …

Long non-coding RNAs in the tumor immune microenvironment: biological properties and therapeutic potential

YN Pi, WC Qi, BR Xia, G Lou, WL Jin - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy (CIT) is considered a revolutionary advance in the fight against
cancer. The complexity of the immune microenvironment determines the success or failure …

The genetics of autoimmune Addison disease: past, present and future

EC Røyrvik, ES Husebye - Nature Reviews Endocrinology, 2022 - nature.com
Autoimmune Addison disease is an endocrinopathy that is fatal if not diagnosed and treated
in a timely manner. Its rarity has hampered unbiased studies of the predisposing genetic …

Reverse-genetics studies of lncRNAs—what we have learnt and paths forward

F Gao, Y Cai, P Kapranov, D Xu - Genome biology, 2020 - Springer
Long non-coding RNAs (lncRNAs) represent a major fraction of the transcriptome in
multicellular organisms. Although a handful of well-studied lncRNAs are broadly recognized …

IPEX syndrome: genetics and treatment options

I Ben-Skowronek - Genes, 2021 - mdpi.com
(1) Background: IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked)
syndrome characterizes a complex autoimmune reaction beginning in the perinatal period …

Long non-coding RNAs (lncRNAs) in response and resistance to cancer immunosurveillance and immunotherapy

GC Eptaminitaki, N Wolff, D Stellas, K Sifakis, S Baritaki - Cells, 2021 - mdpi.com
Long non-coding RNAs (lncRNAs) are critical regulatory elements in cellular functions in
states of both normalcy and disease, including cancer. LncRNAs can influence not only …