Food-derived peptides, as dietary supplements, have significant effects on promoting brain
health and relieving central nervous system (CNS) diseases. However, the blood–brain …

Highlights•Differential levels of 2'-O-methylation in rRNA might contribute to ribosome
specialization in different cell types.•rRNA methylation levels are controlled by regRNPs and …

Repetitive nucleic acid sequences, which occur in abundance throughout the mammalian
genome, are of enormous research interest due to their potential to adopt fascinating and …

RNA is critical to a broad spectrum of biological and viral processes. This functional diversity
is a result of their dynamic nature; the variety of three-dimensional structures that they can …

Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

Cisplatin,(NH3) 2PtCl2, has been known as a successful metal-based anticancer drug for
more than half a century. Its analogue, Argplatin, arginine-linked cisplatin,(Arg) PtCl2, is …

Fluorinated nucleosides are well-established as anticancer and antiviral medications. As
with many pharmaceuticals, the effects of fluorine modifications are often only partially …

Uridine (Urd), a canonical nucleoside of RNA, is the most commonly modified nucleoside
among those that occur naturally. Uridine has also been an important target for the …

Modified nucleosides have been an important target for pharmaceutical development for the
treatment of cancer, herpes simplex virus, and the human immunodeficiency virus (HIV) …

The 2′-substituents distinguish DNA from RNA nucleosides. 2′-O-methylation occurs
naturally in RNA and plays important roles in biological processes. Such 2′-modifications …