Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Currently, in developed countries, nights are excessively illuminated (light at night), whereas
daytime is mainly spent indoors, and thus people are exposed to much lower light intensities …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …

Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the
underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is …

Abstract Histone lysine demethylase 1 (LSD 1), the first identified histone demethylase, is
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …

We found that a neuron-specific isoform of LSD1, LSD1n, which results from an alternative
splicing event, acquires a new substrate specificity, targeting histone H4 Lys20 methylation …

There is a dynamic interplay between metabolic processes and gene regulation via the
remodeling of chromatin. Most chromatin-modifying enzymes use cofactors, which are …