OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence
of calcification may change portions of the arterial conduit to a noncompliant structure …

Abstract Background: Lipoprotein (a)[Lp (a)], a major carrier of oxidized phospholipids
(OxPL), is associated with an increased incidence of aortic stenosis (AS). However, it …

Background: Inflammation drives atherosclerotic plaque rupture. Although inflammation can
be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography …

Aortic stenosis is a common, potentially fatal condition that is set to become an increasing
public health burden. Once symptoms develop, there is an inexorable deterioration with a …

The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …

Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …

Plaque calcification develops by the inflammation-dependent mechanisms involved in
progression and regression of atherosclerosis. Macrophages can undergo two distinct …

Inflammation is a pivotal driver of atherosclerotic plaque progression and rupture and is a
target for identifying vulnerable plaques. However, challenges arise with the current in vivo …

Calcification is a clinical marker of atherosclerosis. This review focuses on recent findings on
the association between calcification and plaque vulnerability. Calcified plaques have …