Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

▪ Abstract GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by
increasing the rates at which their α subunits hydrolyze bound GTP and thus return to the …

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …

▪ Abstract Protein S-palmitoylation is the thioester linkage of long-chain fatty acids to
cysteine residues in proteins. Addition of palmitate to proteins facilitates their membrane …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …

Palmitate, a 16-carbon saturated fatty acid, is attached to more than 100 proteins.
Modification of proteins by palmitate has pleiotropic effects on protein function …

G-protein-coupled receptors (GPCRs) are major targets for drug discovery. The regulator of
G-protein signalling (RGS)-protein family has important roles in GPCR signal transduction …

Palmitoylation is one of the most frequent post-translational modifications found on proteins.
It contributes to membrane association, protein sorting and many other processes. Through …

G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the
human genome. They are subject to numerous post-translational modifications, including …

The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and
Cys of certain eukaryotic proteins, yielding N-terminal Arg that can act as a degradation …