Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …

The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …