This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

Objective: Perform a systematic review of studies reporting on the association between
maternal prenatal cigarette smoking and child overweight. Design: Meta-analysis of …

Background Intrauterine exposure to tobacco smoke has been discerned as an important
risk factor for low birth weight (LBW), small for gestational age (SGA), and preterm birth …

Purpose: To review recent advances in the pathophysiology and potential clinical
applications of leptin, an adipose tissue-derived hormone. Data Sources: A MEDLINE …

Cigarette smoking is the single most important preventable cause of death and illness.
Smoking cessation is associated with substantial health benefits. Weight gain is cited as a …

Objective: To determine the effects of environmental tobacco smoke (ETS) exposure on birth
outcomes. Design: A systematic review and meta-analysis was performed in accordance …

Background: An emerging literature suggests that environmental chemicals may play a role
in the development of childhood obesity and metabolic disorders, especially when exposure …

Leptin: in search of role(s) in human physiology and pathophysiology Page 1 Clinical
Endocrinology (1998) 49, 551–567 Leptin: in search of role(s) in human physiology and …

Corresponding author: CS Mantzoros, MD, D. Sc., Division of Endocrinology, RN 325, Beth
Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA …

This review focuses on current knowledge of leptin biology and the role of leptin in various
physiological and pathophysiological states. Leptin is involved in the regulation of body …