Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …

Abstract Kallikrein-related peptidase 8 (KLK8) acts as an oncogene or anti-oncogene in
various tumours, and the abnormal expression of KLK8 is involved in the carcinogenesis of …

Early diagnosis of cancer and early detection of relapse following surgery are critical for the
effective treatment of the disease and for a positive clinical outcome. Identification of novel …

Background. Tumor tissue-associated KLKs (kallikrein-related peptidases) are clinically
important biomarkers that may allow prognosis of the cancer disease and/or prediction of …

Purpose: Human tissue kallikreins are a family of 15 secreted serine proteases. We have
previously shown that the expression of several tissue kallikreins is significantly altered at …

Purpose The aim of this study was to compare and contrast the expression of all members of
the Kallikrein (KLK) family of genes across 15 cancer types and to evaluate their utility as …

Human kallikrein‐related peptidases (KLKs) are a subgroup of serine proteases that
participate in proteolytic pathways and control protein levels in normal physiology as well as …

Most members of the kallikrein-related peptidase family have been demonstrated to be
dysregulated in ovarian cancer and modulate tumor growth, migration, invasion, and …

Head and neck squamous cell carcinoma (HNSCC) is a world‐wide malignancy. This study
aimed to identify differential gene expression associated with the progression of disease …