Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications
Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
changes in mood. Several pathophysiological mechanisms have been hypothesized to …
Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …
alternate between mania and hypomania or between depression and mixed states, often …
A model of the mitochondrial basis of bipolar disorder
G Morris, K Walder, SL McGee, OM Dean… - Neuroscience & …, 2017 - Elsevier
Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …
availability; increased in mania and decreased in depression. In consort, there is …
The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence
Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …
from these conditions face many impairments regarding personal and professional life. In …
[HTML][HTML] Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond
T Kato - Schizophrenia research, 2017 - Elsevier
Bipolar disorder is one of two major psychotic disorders together with schizophrenia and
causes severe psychosocial disturbance. Lack of adequate animal models hampers …
causes severe psychosocial disturbance. Lack of adequate animal models hampers …
Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics
Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition,
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …
Creatine for the treatment of depression
BM Kious, DG Kondo, PF Renshaw - Biomolecules, 2019 - mdpi.com
Depressed mood, which can occur in the context of major depressive disorder, bipolar
disorder, and other conditions, represents a serious threat to public health and wellness …
disorder, and other conditions, represents a serious threat to public health and wellness …
Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping
Objectives Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic
resonance imaging technique sensitive to pH and other cellular and microstructural factors …
resonance imaging technique sensitive to pH and other cellular and microstructural factors …
Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder
RT de Sousa, R Machado-Vieira… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Bipolar disorder (BPD) is a severe illness with few treatments available.
Understanding BPD pathophysiology and identifying potential relevant targets could prove …
Understanding BPD pathophysiology and identifying potential relevant targets could prove …
Targeting mitochondrial dysfunction for bipolar disorder
M Kuperberg, SLA Greenebaum… - Bipolar Disorder: From …, 2021 - Springer
People with bipolar disorder (BD) all too often have suboptimal long-term outcomes with
existing treatment options. They experience relapsing episodes of depression and mania …
existing treatment options. They experience relapsing episodes of depression and mania …