Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections

RK Shields, DL Paterson… - Clinical Infectious …, 2023 - academic.oup.com
Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

A novel antibiotic class targeting the lipopolysaccharide transporter

C Zampaloni, P Mattei, K Bleicher, L Winther, C Thäte… - Nature, 2024 - nature.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global
pathogen with limited treatment options. No new antibiotic chemical class with activity …

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus …

KS Kaye, AF Shorr, RG Wunderink, B Du… - The Lancet Infectious …, 2023 - thelancet.com
Background An urgent need exists for antibiotics to treat infections caused by carbapenem-
resistant Acinetobacter baumannii–calcoaceticus complex (ABC). Sulbactam–durlobactam …

Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

Y Yang, YH Yan, CJ Schofield, A McNally, Z Zong… - Trends in …, 2023 - cell.com
Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

Colistin monotherapy versus combination therapy for carbapenem-resistant organisms

KS Kaye, D Marchaim, V Thamlikitkul, Y Carmeli… - NEJM …, 2022 - evidence.nejm.org
Background Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant
(XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem …

Mortality attributable to bloodstream infections caused by different carbapenem-resistant gram-negative bacilli: results from a nationwide study in Italy (ALARICO …

M Falcone, G Tiseo, S Carbonara… - Clinical Infectious …, 2023 - academic.oup.com
Background Our aim was to analyze mortality attributable to carbapenem-resistant (CR)
gram-negative bacilli (GNB) in patients with bloodstream infections (BSIs). Methods …

Acinetobacter baumannii in the critically ill: complex infections get complicated

I Cavallo, A Oliva, R Pages, F Sivori, M Truglio… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

Y Jiang, Y Ding, Y Wei, C Jian, J Liu… - Frontiers in microbiology, 2022 - frontiersin.org
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become one of the leading
causes of healthcare-associated infections globally, particularly in intensive care units …

New Drugs for the Treatment of Pseudomonas aeruginosa Infections with Limited Treatment Options: A Narrative Review

AR Losito, F Raffaelli, P Del Giacomo, M Tumbarello - Antibiotics, 2022 - mdpi.com
P. aeruginosa is still one of the most threatening pathogens responsible for serious hospital-
acquired infections. It is intrinsically resistant to many antimicrobial agents and additional …