As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Allergic diseases are significant diseases that affect many patients worldwide. In the past
few decades, the incidence of allergic diseases has increased significantly due to …

Background Food allergy continues to pose problems due to its increased frequency and its
increasingly high severity. In this context, alongside the traditional avoidance strategies of …

Finely tuned mechanisms enable the gastrointestinal tract to break down dietary
components into nutrients without mounting, in the majority of cases, a dysregulated immune …

Background Food-mediated allergic reactions have emerged as a major health problem.
The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary …

Eosinophils natively inhabit the small intestine, but a functional role for them there has
remained elusive. Here, we show that eosinophil-deficient mice were protected from …

Background Little is currently known regarding the immunologic mechanism (s) that initiate
peanut allergy. Notably, peanut proteins have been detected in house dust, and their levels …

The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported
to participate in catechin metabolism in the gut, but this bacterium's effects on immune …

Background A number of food allergies (eg, fish, shellfish, and nuts) are lifelong, without any
disease-transforming therapies, and unclear in their underlying immunology. Clinical …

Background The oral mucosa is the initial interface between food antigens, microbiota, and
mucosal immunity, yet, little is known about oral host-environment dynamics in food allergy …