Advancing immunotherapies for HPV-related cancers: exploring novel vaccine strategies and the influence of tumor microenvironment

AJD Silva, IA Moura, MATM Gama, LRS Leal, SS Pinho… - Vaccines, 2023 - mdpi.com
The understanding of the relationship between immunological responses and cancers,
especially those related to HPV, has allowed for the study and development of therapeutic …

[HTML][HTML] The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology

A Plevriti, M Lamprou, E Mourkogianni, N Skoulas… - Cells, 2024 - mdpi.com
Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and
chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome …

Tumor-suppressive and immunomodulating activity of miR-30a-3p and miR-30e-3p in HNSCC cells and tumoroids

O Conrad, M Burgy, S Foppolo, A Jehl, A Thiéry… - International Journal of …, 2023 - mdpi.com
Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous tumors, well
known for their frequent relapsing nature. To counter recurrence, biomarkers for early …

Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck …

MN Theodoraki, D Huber, L Hofmann, L Werner, C Idel… - BMC cancer, 2024 - Springer
Background Exosomes are closely associated with different aspects of tumor-progression in
patients with head and neck squamous cell carcinoma (HNSCC), such as angiogenesis or …

High infiltration of CD209+ dendritic cells and CD163+ macrophages in the peritumor area of prostate cancer is predictive of late adverse outcomes

OE Molina, H LaRue, D Simonyan… - Frontiers in …, 2023 - frontiersin.org
Introduction Prostate cancer (PCa) shows considerable variation in clinical outcomes
between individuals with similar diseases. The initial host-tumor interaction as assessed by …

Serine and one-carbon metabolism sustain non-melanoma skin cancer progression

A Cappello, A Zuccotti, M Mancini, G Tosetti… - Cell Death …, 2023 - nature.com
Non-melanoma skin cancer (NMSC) is a tumor that arises from human keratinocytes,
showing abnormal control of cell proliferation and aberrant stratification. Cutaneous basal …

Macrophage Profiling in Head and Neck Cancer to Improve Patient Prognosis and Assessment of Cancer Cell–Macrophage Interactions Using Three-Dimensional …

N Mhaidly, F Journe, A Najem, L Stock… - International journal of …, 2023 - mdpi.com
Tumor-associated macrophages are key components of the tumor microenvironment and
play important roles in the progression of head and neck cancer, leading to the development …

Vulvo-vaginal epithelial tumors in mares: A preliminary investigation on epithelial-mesenchymal transition and tumor-immune microenvironment

F Armando, I Porcellato, L de Paolis… - Veterinary …, 2024 - journals.sagepub.com
Vulvo-vaginal epithelial tumors are uncommon in mares, and data on the epithelial-to-
mesenchymal transition (EMT) and the tumor-immune microenvironment (TIME) are still …

Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma

M Wan, X Yang, L He, H Meng - Infectious Agents and Cancer, 2023 - Springer
Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following
Lung cancer. Although some progress has been made in managing laryngeal cancer, the 5 …

[HTML][HTML] Immune cell topography of head and neck cancer

T Muijlwijk, DNLM Nijenhuis… - Journal for …, 2024 - pmc.ncbi.nlm.nih.gov
Background Approximately 50% of head and neck squamous cell carcinomas (HNSCC)
recur after treatment with curative intent. Immune checkpoint inhibitors are treatment options …