The RCSB protein data bank: integrative view of protein, gene and 3D structural information
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB, http://rcsb. org), the US data center for the global PDB archive, makes PDB data freely …
PDB, http://rcsb. org), the US data center for the global PDB archive, makes PDB data freely …
[PDF][PDF] MX1: a bending-magnet crystallography beamline serving both chemical and macromolecular crystallography communities at the Australian Synchrotron
NP Cowieson, D Aragao, M Clift… - Journal of …, 2015 - journals.iucr.org
MX1 is a bending-magnet crystallography beamline at the 3 GeV Australian Synchrotron.
The beamline delivers hard X-rays in the energy range from 8 to 18 keV to a focal spot at the …
The beamline delivers hard X-rays in the energy range from 8 to 18 keV to a focal spot at the …
Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management
D Poger, L Yen, F Braet - Histochemistry and Cell Biology, 2023 - Springer
The second decade of the twenty-first century witnessed a new challenge in the handling of
microscopy data. Big data, data deluge, large data, data compliance, data analytics, data …
microscopy data. Big data, data deluge, large data, data compliance, data analytics, data …
Opportunities and challenges for digital morphology
Advances in digital data acquisition, analysis, and storage have revolutionized the work in
many biological disciplines such as genomics, molecular phylogenetics, and structural …
many biological disciplines such as genomics, molecular phylogenetics, and structural …
A public database of macromolecular diffraction experiments
M Grabowski, KM Langner, M Cymborowski… - Biological …, 2016 - journals.iucr.org
The low reproducibility of published experimental results in many scientific disciplines has
recently garnered negative attention in scientific journals and the general media. Public …
recently garnered negative attention in scientific journals and the general media. Public …
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases
MB Harbut, G Velmourougane… - Proceedings of the …, 2011 - National Acad Sciences
Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an
excellent means of malaria control, drug-resistant parasites necessitate the discovery of new …
excellent means of malaria control, drug-resistant parasites necessitate the discovery of new …
X-ray crystal structure of the streptococcal specific phage lysin PlyC
Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress
from the host. When applied exogenously, these enzymes destroy susceptible microbes …
from the host. When applied exogenously, these enzymes destroy susceptible microbes …
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Current therapeutics and prophylactics for malaria are under severe challenge as a result of
the rapid emergence of drug-resistant parasites. The human malaria parasite Plasmodium …
the rapid emergence of drug-resistant parasites. The human malaria parasite Plasmodium …
The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates
RM Kennan, W Wong, OP Dhungyel, X Han… - PLoS …, 2010 - journals.plos.org
Many bacterial pathogens produce extracellular proteases that degrade the extracellular
matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter …
matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter …
Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors
SN Mistry, N Drinkwater, C Ruggeri… - Journal of medicinal …, 2014 - ACS Publications
Plasmodium parasites, the causative agents of malaria, have developed resistance to most
of our current antimalarial therapies, including artemisinin combination therapies which are …
of our current antimalarial therapies, including artemisinin combination therapies which are …