The RCSB protein data bank: integrative view of protein, gene and 3D structural information

PW Rose, A Prlić, A Altunkaya, C Bi… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB, http://rcsb. org), the US data center for the global PDB archive, makes PDB data freely …

[PDF][PDF] MX1: a bending-magnet crystallography beamline serving both chemical and macromolecular crystallography communities at the Australian Synchrotron

NP Cowieson, D Aragao, M Clift… - Journal of …, 2015 - journals.iucr.org
MX1 is a bending-magnet crystallography beamline at the 3 GeV Australian Synchrotron.
The beamline delivers hard X-rays in the energy range from 8 to 18 keV to a focal spot at the …

Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management

D Poger, L Yen, F Braet - Histochemistry and Cell Biology, 2023 - Springer
The second decade of the twenty-first century witnessed a new challenge in the handling of
microscopy data. Big data, data deluge, large data, data compliance, data analytics, data …

Opportunities and challenges for digital morphology

A Ziegler, M Ogurreck, T Steinke, F Beckmann… - Biology direct, 2010 - Springer
Advances in digital data acquisition, analysis, and storage have revolutionized the work in
many biological disciplines such as genomics, molecular phylogenetics, and structural …

A public database of macromolecular diffraction experiments

M Grabowski, KM Langner, M Cymborowski… - Biological …, 2016 - journals.iucr.org
The low reproducibility of published experimental results in many scientific disciplines has
recently garnered negative attention in scientific journals and the general media. Public …

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases

MB Harbut, G Velmourougane… - Proceedings of the …, 2011 - National Acad Sciences
Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an
excellent means of malaria control, drug-resistant parasites necessitate the discovery of new …

X-ray crystal structure of the streptococcal specific phage lysin PlyC

S McGowan, AM Buckle, MS Mitchell… - Proceedings of the …, 2012 - National Acad Sciences
Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress
from the host. When applied exogenously, these enzymes destroy susceptible microbes …

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

S McGowan, CA Oellig, WA Birru… - Proceedings of the …, 2010 - National Acad Sciences
Current therapeutics and prophylactics for malaria are under severe challenge as a result of
the rapid emergence of drug-resistant parasites. The human malaria parasite Plasmodium …

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates

RM Kennan, W Wong, OP Dhungyel, X Han… - PLoS …, 2010 - journals.plos.org
Many bacterial pathogens produce extracellular proteases that degrade the extracellular
matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter …

Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

SN Mistry, N Drinkwater, C Ruggeri… - Journal of medicinal …, 2014 - ACS Publications
Plasmodium parasites, the causative agents of malaria, have developed resistance to most
of our current antimalarial therapies, including artemisinin combination therapies which are …