RPA and RAD51: fork reversal, fork protection, and genome stability

KP Bhat, D Cortez - Nature structural & molecular biology, 2018 - nature.com
Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …

Repair of strand breaks by homologous recombination

M Jasin, R Rothstein - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled …

RL Coleman, AM Oza, D Lorusso, C Aghajanian… - The Lancet, 2017 - thelancet.com
Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

Control of meiotic crossovers: from double-strand break formation to designation

S Gray, PE Cohen - Annual review of genetics, 2016 - annualreviews.org
Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

The impact of environmental stress on male reproductive development in plants: biological processes and molecular mechanisms

N De Storme, D Geelen - Plant, cell & environment, 2014 - Wiley Online Library
In plants, male reproductive development is extremely sensitive to adverse climatic
environments and (a) biotic stress. Upon exposure to stress, male gametophytic organs …

Homologous recombination and its regulation

L Krejci, V Altmannova, M Spirek… - Nucleic acids research, 2012 - academic.oup.com
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Mechanism of eukaryotic homologous recombination

J San Filippo, P Sung, H Klein - Annu. Rev. Biochem., 2008 - annualreviews.org
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Homologous recombination in DNA repair and DNA damage tolerance

X Li, WD Heyer - Cell research, 2008 - nature.com
Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

F Pâques, JE Haber - Microbiology and molecular biology reviews, 1999 - Am Soc Microbiol
The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …