Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

BACKGROUND: Brain mechanisms of chronic insomnia, a highly prevalent condition, have
barely been investigated. We demonstrate here a decrease in orbitofrontal gray matter (GM) …

Abstract Study Objective: To investigate the structural changes in patients with chronic
primary insomnia and the relationships with clinical features of insomnia. Design: Statistical …

Suicidal behavior is a potentially lethal complication of late-life depression. In younger
adults, suicide has been linked to abnormal decision-making ability. Given that there are …

Deterioration of motor and cognitive performance with advancing age is well documented,
but its cause remains unknown. Animal studies dating back to the late 1970s reveal that age …

The recognition of nonverbal emotional signals and the integration of multimodal emotional
information are essential for successful social communication among humans of any age …

Neuroimaging studies have demonstrated that patients with Alzheimer's disease presented
disconnection syndrome. However, little is known about the alterations of interhemispheric …

Introduction Cerebral small vessel disease (CSVD) is a highly prevalent condition
associated with diffuse ischemic damage and cognitive dysfunction particularly in executive …

Progressive brain atrophy is believed to be the Alzheimer's disease (AD) marker with the
greatest evidence for validity. Mapping the topography of cortical atrophy throughout the …