Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …

Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …

More than a decade ago, the term “next-generation” sequencing was coined to describe
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …

Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are
recognized to cause chronic granulomatous disease (CGD), a severe primary …

Ubiquitin Fold Modifier‐1 (UFM1) is a ubiquitin‐like modifier (UBL) that is posttranslationally
attached to lysine residues on substrates via a dedicated system of enzymes conserved in …

Early-onset epileptic encephalopathy (EE) and combined developmental and epileptic
encephalopathies (DEE) are clinically and genetically heterogeneous severely devastating …

Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …

An ever‐increasing number of neurogenetic conditions presenting with both epilepsy and
atypical movements are now recognized. These disorders within the 'genetic epilepsy …

Intestinal exocrine secretory cells, including Paneth and goblet cells, have a pivotal role in
intestinal barrier function and mucosal immunity. Dysfunction of these cells may lead to the …

Post-translational modification with Ubiquitin-like proteins represents a complex signaling
language regulating virtually every cellular process. Among these post-translational …