[HTML][HTML] Clinical applications and anticancer effects of antimicrobial peptides: from bench to bedside

A Jafari, A Babajani, R Sarrami Forooshani… - Frontiers in …, 2022 - frontiersin.org
Cancer is a multifaceted global health issue and one of the leading causes of death
worldwide. In recent years, medical science has achieved great advances in the diagnosis …

Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges

P Kumbhar, A Manjappa, R Shah, NK Jha… - Journal of Controlled …, 2022 - Elsevier
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …

Nanoparticle‐mediated delivery of inhaled immunotherapeutics for treating lung metastasis

Q Jin, W Zhu, J Zhu, J Zhu, J Shen, Z Liu… - Advanced …, 2021 - Wiley Online Library
Despite the critical breakthrough achieved by immune checkpoint blockade (ICB), the
clinical benefits are usually restricted by inefficient infiltration of immune cells and immune …

Magnetic particle targeting for diagnosis and therapy of lung cancers

M Saadat, MKD Manshadi, M Mohammadi… - Journal of Controlled …, 2020 - Elsevier
Over the past decade, the growing interest in targeted lung cancer therapy has guided
researchers toward the cutting edge of controlled drug delivery, particularly magnetic …

[HTML][HTML] Lipidic lyotropic liquid crystals: Insights on biomedical applications

G Blanco-Fernández, B Blanco-Fernandez… - Advances in Colloid and …, 2023 - Elsevier
Liquid crystals (LCs) possess unique physicochemical properties, translatable into a wide
range of applications. To date, lipidic lyotropic LCs (LLCs) have been extensively explored …

[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …

[HTML][HTML] Hepcidin upregulation in lung cancer: a potential therapeutic target associated with immune infiltration

Y Fan, B Liu, F Chen, Z Song, B Han, Y Meng… - Frontiers in …, 2021 - frontiersin.org
Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating
regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation …

Antimicrobial peptides as novel therapeutics for non-small cell lung cancer

NK Kunda - Drug discovery today, 2020 - Elsevier
Highlights•AMPs can selectively target and destroy cancer cells but not healthy cells.•AMPs
exhibit minimal systemic toxicity and minimal chance for acquiring resistance.•NSCLC cells …

[HTML][HTML] Systematic development and optimization of inhalable pirfenidone liposomes for non-small cell lung cancer treatment

V Parvathaneni, NS Kulkarni, SK Shukla, PT Farrales… - Pharmaceutics, 2020 - mdpi.com
Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain
limited with resistance development by cancer cells and off-target events being major …

Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy

S Xu, Y Xu, NC Solek, J Chen, F Gong… - Advanced …, 2024 - Wiley Online Library
The advancement of message RNA (mRNA)‐based immunotherapies for cancer is highly
dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid …