[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents
PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …
Antiviral agents in development for Zika virus infections
In 1947, Zika virus (ZIKV), a mosquito-borne flavivirus was identified in Uganda and
subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil …
subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil …
Potential antiviral options against SARS-CoV-2 infection
A Ianevski, R Yao, MH Fenstad, S Biza, E Zusinaite… - Viruses, 2020 - mdpi.com
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture
YN Zhang, QY Zhang, XD Li, J Xiong… - Emerging microbes & …, 2020 - Taylor & Francis
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in
China is ongoing worldwide. There are no approved antiviral therapies to treat this viral …
China is ongoing worldwide. There are no approved antiviral therapies to treat this viral …
Identification and tracking of antiviral drug combinations
Combination therapies have become a standard for the treatment for HIV and hepatitis C
virus (HCV) infections. They are advantageous over monotherapies due to better efficacy …
virus (HCV) infections. They are advantageous over monotherapies due to better efficacy …
Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine
PI Andersen, K Krpina, A Ianevski, N Shtaida, E Jo… - Viruses, 2019 - mdpi.com
Viruses are the major causes of acute and chronic infectious diseases in the world.
According to the World Health Organization, there is an urgent need for better control of viral …
According to the World Health Organization, there is an urgent need for better control of viral …
Repurposing host-based therapeutics to control coronavirus and influenza virus
CC Li, XJ Wang, HCR Wang - Drug discovery today, 2019 - Elsevier
Highlights•Drug repositioning is a cost-and time-efficient approach for new
indications.•Targeting host machineries, used by viruses, could develop broad-spectrum …
indications.•Targeting host machineries, used by viruses, could develop broad-spectrum …
Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped
viruses budding and release from the producer cells, viral envelope glycoproteins are …
viruses budding and release from the producer cells, viral envelope glycoproteins are …
Zika virus: origins, pathological action, and treatment strategies
K Gorshkov, SA Shiryaev, S Fertel, YW Lin… - Frontiers in …, 2019 - frontiersin.org
The Zika virus (ZIKV) global epidemic prompted the World Health Organization to declare it
a 2016 Public Health Emergency of International Concern. The overwhelming experience …
a 2016 Public Health Emergency of International Concern. The overwhelming experience …
Interferon-inducer antivirals: Potential candidates to combat COVID-19
Abstract Coronavirus disease 2019 (COVID-19) is an infective disease generated by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the pandemic urgency and …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the pandemic urgency and …