Tuberculosis drug discovery: challenges and new horizons
GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Targeting mycobacterial membranes and membrane proteins: Progress and limitations
Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …
Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …
times and still possesses serious threat across the globe. Each year the number of cases …
Drug-resistance in Mycobacterium tuberculosis: where we stand
A Mabhula, V Singh - Medchemcomm, 2019 - pubs.rsc.org
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
Extreme Drug Tolerance of Mycobacterium abscessus “Persisters”
Persistence of infection despite extensive chemotherapy with antibiotics displaying low MICs
is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the …
is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the …
An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus
K Zhang, J Limwongyut, AS Moreland… - Science Translational …, 2024 - science.org
Infections caused by nontuberculous mycobacteria have increased more than 50% in the
past two decades and more than doubled in the elderly population. Mycobacterium …
past two decades and more than doubled in the elderly population. Mycobacterium …
Advances in key drug target identification and new drug development for tuberculosis
J Mi, W Gong, X Wu - BioMed Research International, 2022 - Wiley Online Library
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …
Mycobacterial membranes as actionable targets for lipid-centric therapy in tuberculosis
B Modak, S Girkar, R Narayan… - Journal of Medicinal …, 2022 - ACS Publications
Infectious diseases remain significant health concerns worldwide, and resistance is
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …
particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis …
[HTML][HTML] Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents
Indole-containing small molecules have been reported to have diverse pharmacological
activities. The aromatic heterocyclic scaffold, which resembles various protein structures …
activities. The aromatic heterocyclic scaffold, which resembles various protein structures …
Nanomolar effective report of tetra-cationic silver (II) porphyrins against non-tuberculous mycobacteria in antimicrobial photodynamic approaches
KB Guterres, GG Rossi, MMA de Campos… - Photodiagnosis and …, 2022 - Elsevier
We report the photoinactivation evaluation of Ag (II) porphyrins (cationic AgTMeP and
anionic AgTPPS) in the antimicrobial photodynamic therapy (aPDT) of rapidly growing …
anionic AgTPPS) in the antimicrobial photodynamic therapy (aPDT) of rapidly growing …