Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …

Aged and degenerated intervertebral discs are characterised by a significant increase in the
number of senescent cells, which may be associated with the deterioration of this tissue due …

Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a
condition that represents a serious socio-economic burden. Deeper knowledge of the …

Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …

Purpose Mechanical loading represents an integral part of intervertebral disc (IVD)
homeostasis. This review aims to summarise recent knowledge on the effects of mechanical …

Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a
severe public health problem worldwide. Current therapy for IDD aims to alleviate the …

Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a
progressive loss of the IVD structure and functionality, leading to severe impairments with …

Intervertebral disc (IVD) degeneration (IDD) is the most common cause leading to low back
pain (LBP), which is a highly prevalent, costly, and crippling condition worldwide. Current …

Tissue engineering has promising applications in the treatment of intervertebral disc
degeneration (IDD). The annulus fibrosus (AF) is critical for maintaining the physiological …