Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

The comprehensive anabolic effects of insulin throughout the body, in addition to the control
of glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation …

Increasing evidence suggests that migraine may be the result of an impaired brain glucose
metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain …

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when
overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the …

The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin
signaling pathways. The IR has been considered as a novel therapeutic target for clinical …

The number of people with diabetes worldwide is increasing annually, resulting in a serious
economic burden. Insulin resistance is a major pathology in the early onset of diabetes …

Context Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of
reproductive-aged women. In pregnancy, women with PCOS experience increased risk of …

Context Placental transport capacity influences fetal glucose supply. The syncytiotrophoblast
is the transporting epithelium in the human placenta, expressing glucose transporters …

This study aimed to identify epigenetic alternations of microRNAs and DNA methylation for
gestational diabetes mellitus (GDM) diagnosis and treatment using in silico approach. Data …