Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …

Metabolic changes contribute to cancer initiation and progression through effects on cancer
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …

Purine nucleotides are necessary for various biological processes related to cell
proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and …

Summary Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three
mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant …

Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon
(1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase …

Metabolic rewiring is essential for cancer onset and progression. We previously showed that
one-carbon metabolism-dependent formate production often exceeds the anabolic demand …

In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are
original were designed and synthesized. Cytotoxicity assay indicated that most of these …

Numerous studies have demonstrated that individual proteins can moonlight. Eukaryotic
Initiation translation factor 3, f subunit (eIF3f) is involved in critical biological functions; …

Mitochondria‐targeted therapeutics are an attractive approach against energy‐dependent
cancer. However, effective mitochondria organelle therapeutics agents are still highly …

Cells execute biological functions to support phenotypes such as growth, migration, and
secretion. Complementarily, each function of a cell has resource costs that constrain …