Epidemiological and clinical data indicate high comorbidity between depression and drug
dependence that may reflect an attempt to self-medicate with drugs of abuse. The present …

In this review, we describe the evolutionary process involved in the discovery of the selective
5-HT uptake inhibitor, fluoxetine, and summarize some of the large body of scientific …

Synopsis: Fluoxetine 1 is a new antidepressant which enhances serotoninergic
neurotransmission through potent and selective inhibition of neuronal reuptake of serotonin …

5-Hydroxytryptamine2A (serotonin2A, 5-HT2A) receptors are important for many physiologic
processes including platelet aggregation, smooth muscle contraction, and the modulation of …

• Considerable evidence suggests that the acute effects of antidepressant treatments on
brain norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their …

• We conducted an open clinical trial of desipramine hydrochloride or lithium carbonate as
adjuncts to psychotherapy in cocaine abusers. Subjects who were treated with desipramine …

Fluoxetine is a bicyclic antidepressant that is a specific and potent inhibitor of the
presynaptic reuptake of serotonin. It has essentially no effect on the reuptake of …

The neurochemical and autonomic pharmacological profile of l, 2, 3, 4, 10, 14b-hexahydro-2-
methyl-pyrazino [2, 1-a] pyrido [2, 3-c][2] benzazepine (±) Org 3770) and the related …

The effects of acute and chronic antidepressant treatment on various aspects of 5-HT
neurotransmission are reviewed, in order to assess the net effect of antidepressants on …

• The most predictable anxiolytic effects of neurotransmitters are linked to the activation of a
β-aminobutytic acid (GABA)—ergic subsystem associated with specific benzodiazepine …