Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Angiogenesis has been associated with the growth, dissemination, and metastasis of solid
tumors. The aims of this study were to evaluate the vascularity and the levels of angiogenic …

Research in the last few years has revealed a sophisticated interaction network between
multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties …

Besides its role as an essential regulator of physiologic and pathologic angiogenesis,
vascular endothelial growth factor (VEGF) triggers growth, survival, and migration of …

We report a method of purifying, characterizing and expanding endothelial cells (ECs)
derived from CD133+ bone marrow cells, a subset of CD34+ haematopoietic progenitors …

Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly
diagnosed cancer patients by means of 4-color flow cytometry. In breast cancer (n= 46) and …

Similar to solid tumors, growth of leukemias may also be angiogenesis dependent.
Furthermore, tyrosine kinase receptors specific to endothelial cells are expressed on certain …

Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide with biologic
effects that include regulation of hematopoietic stem cell development, extracellular matrix …

Thalidomide was administered to 83 patients with myelodysplastic syndrome (MDS), starting
at 100 mg by mouth daily and increasing to 400 mg as tolerated. Thirty-two patients stopped …