[HTML][HTML] Histone deacetylases and cancer
B Barneda-Zahonero, M Parra - Molecular oncology, 2012 - Elsevier
Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …
[HTML][HTML] Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect
The histone deacetylase inhibitors (HDACi) have demonstrated anticancer efficacy across a
range of malignancies, most impressively in the hematological cancers. It is uncertain …
range of malignancies, most impressively in the hematological cancers. It is uncertain …
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against …
W Fiskus, Y Wang, A Sreekumar… - Blood, The Journal …, 2009 - ashpublications.org
The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …
Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis
A Clocchiatti, C Florean… - Journal of cellular and …, 2011 - Wiley Online Library
Introduction• General concepts on class IIa HDACs‐Regulation of subcellular localization‐
Binding partners‐Catalytic activity‐Class IIa HDAC orthologues in model organisms• …
Binding partners‐Catalytic activity‐Class IIa HDAC orthologues in model organisms• …
The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasms
K Wenzl, K Troppan, P Neumeister… - Current drug …, 2015 - ingentaconnect.com
NR4A1 (Nur77) belongs together with NR4A2 (Nurr1) and NR4A3 (NOR-1) to the nuclear
orphan receptors of the NR4A-family. Their activation is generally short lived, the cellular …
orphan receptors of the NR4A-family. Their activation is generally short lived, the cellular …
The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL‐10 expression in cutaneous T‐cell lymphoma cells
CE Tiffon, JE Adams, L Van Der Fits… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Vorinostat and romidepsin are histone deacetylase
inhibitors (HDI), approved for the treatment of cutaneous T‐cell lymphoma (CTCL). However …
inhibitors (HDI), approved for the treatment of cutaneous T‐cell lymphoma (CTCL). However …
Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells
A Wang, J Rud, CM Olson, J Anguita… - The Journal of …, 2009 - journals.aai.org
Nur77, an orphan nuclear receptor, plays a key role in apoptosis in T cells. In cancer cell
lines, Nur77 can induce apoptosis through the intrinsic apoptotic pathway, but the …
lines, Nur77 can induce apoptosis through the intrinsic apoptotic pathway, but the …
Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients
BM Cyrenne, JM Lewis, JG Weed… - Blood, The Journal …, 2017 - ashpublications.org
The presence and degree of peripheral blood involvement in patients with cutaneous T-cell
lymphoma (CTCL) portend a worse clinical outcome. Available systemic therapies for CTCL …
lymphoma (CTCL) portend a worse clinical outcome. Available systemic therapies for CTCL …
HDAC inhibitors for the treatment of cutaneous T-cell lymphomas
S Rangwala, C Zhang, M Duvic - Future medicinal chemistry, 2012 - Taylor & Francis
Epigenetic modification by small-molecule histone deacetylase inhibitors (HDAC-Is) has
been a promising new antineoplastic approach for various solid and hematological …
been a promising new antineoplastic approach for various solid and hematological …
HDAC inhibitors and cancer therapy
PW Atadja - Epigenetics and Disease: Pharmaceutical …, 2011 - Springer
Maintenance of normal cell growth and differentiation is highly dependent on coordinated
and tight transcriptional regulation of genes. In cancer, genes encoding growth regulators …
and tight transcriptional regulation of genes. In cancer, genes encoding growth regulators …