Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …

Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be
stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Although several epidemiologic and animal studies have revealed correlations between
obesity and neurodegenerative disorders, such as Parkinson disease (PD), the underlying …

Highlights•GW501516 reduces movement impairment of PD mice.•GW501516 attenuates
dopaminergic neuronal degeneration in the midbrain of PD mice as well as dopamin loss in …

Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD)
and even appear as early symptoms. Here we investigated the therapeutic potential of …

The kexin-like proprotein convertases perform the initial proteolytic cleavages that ultimately
generate a variety of different mature peptide and proteins, ranging from brain …

This study explores the intriguing phenomenon of action potentials reverberating and
propagating in high-resistance tissues, such as gliosis, leading to the emergence of short …

ABSTRACT PD (PD) is a debilitating progressive age-related neurodegenerative disorder
that negatively impacts bodily movement. It is the second most common type of …