Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro
model to recapitulate human brain development and neurological diseases. However, the …
model to recapitulate human brain development and neurological diseases. However, the …
[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …
computing in terms of faster decision-making, continuous learning during tasks, and greater …
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells
Cortico-striatal projections are critical components of forebrain circuitry that regulate
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …
Challenges of organoid research
MG Andrews, AR Kriegstein - Annual review of neuroscience, 2022 - annualreviews.org
Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …
contain tissue resident cell types and reflect features of early tissue organization. Neural …
Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
Rethinking organoid technology through bioengineering
In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis
S Gribaudo, R Robert, B van Sambeek, C Mirdass… - Nature …, 2024 - nature.com
Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …
systemic events underlying development and disease. Here we report the generation of …
[HTML][HTML] Complex oscillatory waves emerging from cortical organoids model early human brain network development
Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …
developmental programs defined by genetics. However, whether this is true for functional …