Engineering organoids

M Hofer, MP Lutolf - Nature Reviews Materials, 2021 - nature.com
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo

I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

AN Cho, Y Jin, Y An, J Kim, YS Choi, JS Lee… - Nature …, 2021 - nature.com
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro
model to recapitulate human brain development and neurological diseases. However, the …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

Y Miura, MY Li, F Birey, K Ikeda, O Revah… - Nature …, 2020 - nature.com
Cortico-striatal projections are critical components of forebrain circuitry that regulate
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …

Challenges of organoid research

MG Andrews, AR Kriegstein - Annual review of neuroscience, 2022 - annualreviews.org
Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …

Human brain organogenesis: Toward a cellular understanding of development and disease

KW Kelley, SP Pașca - Cell, 2022 - cell.com
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Rethinking organoid technology through bioengineering

E Garreta, RD Kamm, SM Chuva de Sousa Lopes… - Nature materials, 2021 - nature.com
In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …

Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis

S Gribaudo, R Robert, B van Sambeek, C Mirdass… - Nature …, 2024 - nature.com
Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

[HTML][HTML] Complex oscillatory waves emerging from cortical organoids model early human brain network development

CA Trujillo, R Gao, PD Negraes, J Gu, J Buchanan… - Cell stem cell, 2019 - cell.com
Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …