Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of breast cancer. Methods For the 2007 update, an …

Application of stem cell biology to breast cancer research has been limited by the lack of
simple methods for identification and isolation of normal and malignant stem cells. Utilizing …

Purpose To determine the prognostic significance of triple negative breast cancers with
respect to locoregional relapse and distant metastasis in conservatively managed breast …

Profiling breast cancer with expression arrays has become common, and it has been
suggested that the results from early studies will lead to understanding of the molecular …

A better molecular characterization of breast cell lines (BCL) may help discover new markers
to apply to tumour samples. We performed gene and protein expression profiling of 31 BCL …

Breast cancer is a group of heterogeneous diseases that show substantial variation in their
molecular and clinical characteristics. This heterogeneity poses significant challenges not …

Basal and luminal are two molecular subtypes of breast cancer with opposite histoclinical
features. We report a combined, high-resolution analysis of genome copy number and gene …

How breast cancers are able to disseminate and metastasize is poorly understood. Using a
hyperplasia transplant system, we show that tumor dissemination and metastasis occur in …

DNA microarray profiling studies have led to the classification of invasive breast carcinoma
into luminal/estrogen receptor–positive, normal breast–like, Her2/neu-overexpressing, and …