CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases.
However, its therapeutic applications are limited by unintended genomic alterations arising …

The MutL family of DNA mismatch repair proteins (MMR) acts to maintain genomic integrity
in somatic and meiotic cells. In baker's yeast, the MutL homolog (MLH) MMR proteins form …

Highlights•Dissolution by BLM-TopoIIIα-RMI1–RMI2 leads to non-crossovers only.•Unbiased
resolution by GEN1, MUS81 and SLX1 leads to crossovers and non-crossovers.•MLH1 …

Somatic expansion of the CAG repeat tract that causes Huntington's disease (HD) is thought
to contribute to the rate of disease pathogenesis. Therefore, factors influencing repeat …

In budding yeast, the MutL homolog heterodimer Mlh1-Mlh3 (MutLγ) plays a central role in
the formation of meiotic crossovers. It is also involved in the repair of a subset of mismatches …

FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in
which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) …

Topoisomerases are enzymes that relax DNA supercoiling during replication and
transcription. Camptothecin, a topoisomerase 1 (TOP1) inhibitor, and its analogs trap TOP1 …

Germline mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2
are linked to cancer of the colon and other organs, characterized by microsatellite instability …

In a comprehensive study to decipher the multi-layered response to the chemotherapeutic
agent temozolomide (TMZ), we analyzed 427 genomes and determined mutational patterns …

DNA repair by homologous recombination (HR) is critical for the maintenance of genome
stability. Germline and somatic mutations in HR genes have been associated with an …