[HTML][HTML] Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile

C Miranda-Vera, ÁP Hernández, P García-García… - Pharmaceutics, 2023 - mdpi.com
Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …

Light on the horizon: current research and future perspectives in flow photochemistry

F Politano, G Oksdath-Mansilla - Organic Process Research & …, 2018 - ACS Publications
Synthetic organic photochemistry is a powerful tool for creating both natural products and
molecules with high structural complexity in a simple way and under mild conditions …

Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐b]thiophenes via Michael addition reaction

EM Eid, HME Hassaneen… - Journal of …, 2020 - Wiley Online Library
A synthesis of novel series of bis (2‐amino‐3‐cyano‐4 H‐chromene), bis (2‐amino‐3‐
cyanopyrano [3, 2‐c] chromene), bis (6‐amino‐5‐cyano‐1, 4‐dihydropyrano [2, 3‐c] …

[HTML][HTML] A novel cytotoxic conjugate derived from the natural product podophyllotoxin as a direct-target protein dual inhibitor

ÁP Hernández, P Díez, PA García, M Pérez-Andrés… - Molecules, 2020 - mdpi.com
Natural products are the ideal basis for the design of novel efficient molecular entities.
Podophyllotoxin, a naturally occurring cyclolignan, is an example of natural product which …