Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …

Gastric cancer (GC), a heterogeneous disease characterized by epidemiologic and
histopathologic differences across countries, is a leading cause of cancer-related death …

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical
characteristics has been complicated by histological and aetiological heterogeneity. Here …

We are in an era where the potential exists for deriving comprehensive profiles of DNA
alterations characterizing each form of human cancer. Such profiles would provide …

DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of
human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor
suppressor p16 has continued to gain widespread importance in cancer. The high frequency …

Purpose The current classification systems of myelodysplastic syndromes (MDS), including
the International Prognostic Scoring System (IPSS), do not fully reflect the molecular …