Photoactive technology has proven successful for non-invasive regulation of biological
activities and processes in living cells. With the light-directed generation of biomaterials or …

The ability to specifically attach chemical probes to individual proteins represents a powerful
approach to the study and manipulation of protein function in living cells. It provides a …

The conjugation of proteins with synthetic molecules can be conducted in many different
ways. In this Perspective, we focus on tag-based techniques and specifically on the SNAP …

Assessment of protein dynamics in living cells is crucial for understanding their biological
properties and functions. The SNAP‐tag, a self labeling suicide enzyme, presents a tool with …

Site-directed RNA editing allows for the manipulation of RNA and protein function by
reprogramming genetic information at the RNA level. For this we assemble artificial RNA …

The natural mechanisms that direct proteins to membranes are typically complex, requiring
multiple steps and accessory components. It would be advantageous to develop simplified …

The photoactivatable chemically induced dimerization (photo‐CID) technique for tag‐fused
proteins is one of the most promising methods for regulating subcellular protein …

The site-selective, oriented, covalent immobilization of proteins on surfaces is an important
issue in the establishment of microarrays, biosensors, biocatalysts, and cell assays. Here we …

Chemical biology aims for a perfect control of protein complexes in time and space by their
site-specific labeling, manipulation, and structured organization. Here we developed a self …

Selective labeling of the protein of interest (POI) in genetically unmodified live cells is crucial
for understanding protein functions and kinetics in their natural habitat. In particular …