Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast
number of physiological and pathological processes. Sphingomyelin (SM) is the most …

Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized
as critical regulators of inflammatory processes during myocardial ischemia and reperfusion …

Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase
(NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …

Rationale: Macrophage migration inhibitory factor (MIF) is released on platelet activation.
Circulating MIF could potentially regulate platelets and thereby platelet-mediated …

Sphingolipids in general and ceramides in particular, contribute to pathophysiological
mechanisms by modifying signalling and metabolic pathways. Here, we present the …

Platelet integrity and function critically depend on lipid composition. However, the lipid
inventory in platelets was hitherto not quantified. Here, we examined the lipidome of murine …

Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the
main trigger of platelet activation und acute arterial thrombotic occlusion leading to …

Recent data highlight the important roles of the gut microbiome, gut permeability, and
alterations in mitochondria functioning in the pathophysiology of multiple sclerosis (MS) …