The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …

Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Depression is a significant public health problem, but its etiology and pathophysiology
remain poorly understood. Such incomplete understanding likely arises from the fact that …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells …

A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Stress is thought to influence human eating behavior and has been examined in animal and
human studies. Our understanding of the stress-eating relation is confounded by limitations …

Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β)
may play a pivotal role in the central nervous system (CNS) inflammation of depression …