Taurine is often referred to as a semi‐essential amino acid as newborn mammals have a
limited ability to synthesize taurine and have to rely on dietary supply. Taurine is not thought …

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as
during cell division, growth, migration and cell death. Mammalian cells adjust their volume …

Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment,
the determinants of tumor cell responsiveness remain poorly understood. We show that the …

Cell volume regulation (CVR) is essential for all types of cells in the central nervous system
(CNS) to counteract cell volume changes that may be associated with neuronal activities or …

There are a number of mammalian anion channel types associated with cell volume
changes. These channel types are classified into two groups: volume-activated anion …

Cancer remains a leading cause of death worldwide, despite many advances being made in
recent decades. Changes in the tumor microenvironment, including dysregulated immunity …

Key points Swelling‐activated anion currents are modulated by oxidative conditions, but it is
unknown if oxidation acts directly on the LRRC8 channel‐forming proteins or on regulatory …

The leucine-rich repeat containing 8A (LRRC8A) protein is an essential component of the
volume-sensitive organic anion channel (VSOAC), and using pharmacological anion …

Cisplatin resistance is a major challenge in the treatment of cancer and develops through
reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell …

Abstract Bio-functionalized three-dimensional (3D) structures fabricated by direct laser
writing (DLW) are structurally and mechanically well-defined and ideal for systematically …