Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
[HTML][HTML] Systems biology of malaria explored with nonhuman primates
MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
[HTML][HTML] Key criteria for the ethical acceptability of COVID-19 human challenge studies: Report of a WHO Working Group
This report of the WHO Working Group for Guidance on Human Challenge Studies in COVID-
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …
19 outlines ethical standards for COVID-19 challenge studies. It includes eight Key Criteria …
[PDF][PDF] Key criteria for the ethical acceptability of COVID-19 human challenge studies
World Health Organization - 2020 - apps.who.int
The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, poses an
extraordinary threat to global public health, socioeconomic stability, food security and other …
extraordinary threat to global public health, socioeconomic stability, food security and other …
Payment in challenge studies: ethics, attitudes and a new payment for risk model
Controlled Human Infection Model (CHIM) research involves the infection of otherwise
healthy participants with disease often for the sake of vaccine development. The COVID-19 …
healthy participants with disease often for the sake of vaccine development. The COVID-19 …
Promoting ethical payment in human infection challenge studies
To prepare for potential human infection challenge studies (HICS) involving SARS-CoV-2,
we convened a multidisciplinary working group to address ethical questions regarding …
we convened a multidisciplinary working group to address ethical questions regarding …
Human infection challenge studies in endemic settings and/or low-income and middle-income countries: key points of ethical consensus and controversy
E Jamrozik, MJ Selgelid - Journal of Medical Ethics, 2020 - jme.bmj.com
Human infection challenge studies (HCS) involve intentionally infecting research
participants with pathogens (or other micro-organisms). There have been recent calls for …
participants with pathogens (or other micro-organisms). There have been recent calls for …
Volunteering for infection: participant perspectives on a hepatitis C virus controlled human infection model
JD Eberts, P Zimmer-Harwood… - Clinical Infectious …, 2023 - academic.oup.com
Ethical human subjects research requires participants to be treated safely and respectfully,
yet much bioethical debate takes place without participants. We aim to address this gap in …
yet much bioethical debate takes place without participants. We aim to address this gap in …
[HTML][HTML] When could human challenge trials be deployed to combat emerging infectious diseases? Lessons from the case of a Zika virus human challenge trial
R Palacios, SK Shah - Trials, 2019 - Springer
Human challenge trials (HCTs) deliberately infect participants in order to test vaccines and
treatments in a controlled setting, rather than enrolling individuals with natural exposure to a …
treatments in a controlled setting, rather than enrolling individuals with natural exposure to a …
[HTML][HTML] Ethical considerations around volunteer payments in a malaria human infection study in Kenya: an embedded empirical ethics study
Abstract Human Infection Studies (HIS) have emerged as an important research approach
with the potential to fast track the global development of vaccines and treatments for …
with the potential to fast track the global development of vaccines and treatments for …