Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular
metabolism. ROS play a crucial role in the physiological processes and signalling pathways …

Ageing is a process characterized by a progressive decline in cellular function, organismal
fitness and increased risk of age-related diseases and death. Several hundred theories …

Infection and inflammation are relevant entities of male reproductive disorders that can lead
to sub-/infertility. Associated damage of the testis of affected men and in rodent models …

There is growing concern that some cytotoxic regimens for cancer adversely affect
spermatogenesis and male fertility. Increasing evidence demonstrated that melatonin has …

The NR4A subfamily of nuclear receptors consists of three mammalian members: Nur77,
Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes …

Mitogen‐activated protein kinases (MAPKs) comprise a family of serine/threonine kinases
that are activated by a large variety of extracellular stimuli and play integral roles in …

Abstract Epigallocatechin-3-gallate (EGCG), a bioactive polyphenol in green tea, exerts
antiapoptotic activity and prevents tissue damage against different stimuli. Herein, we …

Parkinson's disease (PD) is a neurodegenerative disorder for which a greater prevalence
and incidence is described in men. This suggests a protective effect of sex hormones in the …

Aims: Testis and sperm are particularly susceptible to inflammation and oxidative stress.
Although hydrogen sulfide (H2S) has been considered an important biological signaling …

Late-onset hypogonadism (LOH) is closely related to secondary androgen deficiency in
aged males, but the mechanism remains unclear. In this study, we found that reduced …