Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …

Emerging evidence suggests that altered myelination is an important pathophysiologic
correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's …

Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …

Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative
period by older adults, and is associated with postoperative cognitive dysfunction (POCD) …

Abstract Changes in myelination are a cardinal feature of brain development and the
pathophysiology of several central nervous system diseases, including multiple sclerosis …

Stiffness of the large arteries has been shown to impact cerebral white matter (WM)
microstructure in both younger and older adults. However, no study has yet demonstrated an …

Myelin's role in processing speed is pivotal, as it facilitates efficient neural conduction. Its
decline could significantly affect cognitive efficiency during ageing. In this work, myelin …

Gait speed is a robust health biomarker in older adults, correlating with the risk of physical
and cognitive impairments, including dementia. Myelination plays a crucial role in …

Objective To investigate the relationship between changes in cerebral blood flow (CBF) and
gray matter (GM) microstructure in Alzheimer's disease (AD) and mild cognitive impairment …

Abstract The Human Connectome Project Lifespan studies cover the Development (5-21)
and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging …